Gene Involved in the 3 q 27 Translocation Associated With B - Cell Lymphoma , BCLS , Encodes a Kruppel - Like Zinc - Finger Protein
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چکیده
Chromosomal translocations involving band 3q27 are the recently described nonrandom cytogenetic abnormalities in B-cell malignancies. We have previously cloned the breakpoint region of 3q27, designated as the BCf5 locus, from the B-cell line carrying the t(3; 22). The cDNA for the BCf5 gene was cloned from the human liver cDNA library. The nucleotide sequencing analysis showed that the BCLB gene encodes a potential transcription factor containing six repeats of the Cys2-His2 zinc-finger motif resembling the Drosophila segmentation gene Kruppel. The calculated molecular weight was 78.8 kD, which was supported by an in vitro transcription and translation experiment. A part
منابع مشابه
Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Krüppel-like zinc-finger protein.
Chromosomal translocations involving band 3q27 are the recently described nonrandom cytogenetic abnormalities in B-cell malignancies. We have previously cloned the breakpoint region of 3q27, designated as the BCL5 locus, from the B-cell line carrying the t(3;22). The cDNA for the BCL5 gene was cloned from the human liver cDNA library. The nucleotide sequencing analysis showed that the BCL5 gene...
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تاریخ انتشار 2002